Structure of PDB 5w1l Chain A

Receptor sequence

>5w1lA (length=584) Species: 6210 (Echinococcus granulosus) [Search protein sequence]

SAEQVEKLRNKINNAAVLVFAKSFCPYCKKVMERFNNLKIPFGYLDLDLK
KNGSDYQKMLQEITGRTTVPQVFFRGEFIGGCDDVMAIDDDTIVKKANEM
KYDYDMVIIGGGSGGLALAKESAKSGAKVALLDFVVPTPMGTTWGLGGTC
VNVGCIPKKLMHQAALLNHYMEDAKSFGWDVDKGPHDWVKMVEGIQDHIH
ALNFGYRSSMMNANVKYLNALGEIVDPHTIKTTNKQGIVKNITTNTIIVA
TGERPRYPPIPGAKEYGITSDDLFTLDHNPGKTLCVGASYVSLECAGFLS
SIGCDVTVMVRSIFLRGFDQQMAGLISDYIAKYGVKFVRPCVPTSVRCLE
EYDPESGKLAIYEVEGKHEDGTPFKDTFNTVLFAVGRDPCTTNIGLQNVD
VKTTNGRVVVDDEERTNVPNIYAIGDVSNAGYQLTPLAIQAGKNLARRLY
TADDCRTDYTNVPTTVFTPLEYGCIGLSEENAISKFGEDNIEVFHSYFQP
LEWTVPHRPDNTCYAKLIINKQDDNRVVGFHVFGPNAGEVTQGYAVAMHL
GARKEDFDRTIGIHPTCSETFTTLRVTKSSGASA

3D structure

PDB

5w1l The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I).

Chain

Resolution

2.88 Å

3D
structure

Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Catalytic site (original residue number in PDB)	L152 C156 C161 K164 Y296 E300 G568 H570 E575
Catalytic site (residue number reindexed from 1)	L146 C150 C155 K158 Y290 E294 G562 H564 E569
Enzyme Commision number	1.8.1.9: thioredoxin-disulfide reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	I115 G116 G118 D139 F140 G154 T155 G160 C161 K164 L227 G228 T257 G258 Y296 V297 R393 G431 D432 Q439 L440 T441	I109 G110 G112 D133 F134 G148 T149 G154 C155 K158 L221 G222 T251 G252 Y290 V291 R387 G425 D426 Q433 L434 T435
BS02	AU	A	F504 P506 C519 C573	F498 P500 C513 C567

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0004362	glutathione-disulfide reductase (NADPH) activity
GO:0004791	thioredoxin-disulfide reductase (NADPH) activity
GO:0016491	oxidoreductase activity
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660	flavin adenine dinucleotide binding

	Biological Process
GO:0006749	glutathione metabolic process
GO:0034599	cellular response to oxidative stress
GO:0045454	cell redox homeostasis
GO:0098869	cellular oxidant detoxification

	Cellular Component
GO:0005739	mitochondrion
GO:0005829	cytosol

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5w1l, PDBe:5w1l, PDBj:5w1l
PDBsum	5w1l
PubMed	28463568
UniProt	Q869D7

[Back to BioLiP]