Structure of PDB 5w0o Chain A

Receptor sequence
>5w0oA (length=338) Species: 9606 (Homo sapiens) [Search protein sequence]
LEPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIRQD
FPGTKLSLFGSSKNGFGFKQSDLDVCMTINGLGLDCVRTIEELARVLRKH
SGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSAYSAI
DPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNPPVIP
VLQEIPEIFVDGWNIYFFDQIDELPTYWSECGKNTESVGQLWLGLLRFYT
EEFDFKEHVISIRRKSLLTTFKKQWTSIVIEDPFDLNHNLGAGLSRKMTN
FIMKAFINGRRVFGIPVKGFPKDYPSKMEYFFDPDVLT
3D structure
PDB5w0o Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
ChainA
Resolution2.488 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.52: RNA uridylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A I1099 A1102 K1103 V1104 N1124 A1163 S1164 I109 A112 K113 V114 N134 A173 S174
BS02 rna A L1097 I1099 R1165 L107 I109 R175
BS03 UTP A F1045 G1046 S1047 N1050 N1130 K1152 S1170 Y1171 T1174 L1288 F59 G60 S61 N64 N140 K162 S180 Y181 T184 L290
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5w0o, PDBe:5w0o, PDBj:5w0o
PDBsum5w0o
PubMed28671666
UniProtQ5VYS8|TUT7_HUMAN Terminal uridylyltransferase 7 (Gene Name=TUT7)

[Back to BioLiP]