Structure of PDB 5w0n Chain A

Receptor sequence

>5w0nA (length=379) Species: 9606 (Homo sapiens) [Search protein sequence]

IQLEPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIR
QDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGLETAEGLDCVRTIEELA
RVLRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLL
SAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQR
NPPVIPVLQEIYKGEKKPEIFVDGWNIYFFDQIDELPTYWSECGKNTESV
GQLWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEDPFDL
NHNLGAGLSRKMTNFIMKAFINGRRVFGIPVKGFPKDYPSKMEYFFDPDV
LTEGELAPNDRCCRICGKIGHFMKDCPMR

3D structure

PDB

5w0n Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.

Chain

Resolution

2.497 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.52: RNA uridylyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MG	A	D1058 D1060	D74 D76
BS02	2KH	A	F1045 G1046 S1047 S1057 D1058 D1060 N1130 K1152 S1170 Y1171 L1288	F61 G62 S63 S73 D74 D76 N146 K168 S186 Y187 L304
BS03	UPU	A	F1045 D1060 I1099 V1104 I1106 N1124 S1164 I1353 G1354 H1355	F61 D76 I115 V120 I122 N140 S180 I369 G370 H371
BS04	ZN	A	C1347 C1350 H1355 C1360	C363 C366 H371 C376

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0008270	zinc ion binding

View graph for
Molecular Function

External links

PDB	RCSB:5w0n, PDBe:5w0n, PDBj:5w0n
PDBsum	5w0n
PubMed	28671666
UniProt	Q5VYS8\|TUT7_HUMAN Terminal uridylyltransferase 7 (Gene Name=TUT7)

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