Structure of PDB 5w0f Chain A

Receptor sequence
>5w0fA (length=114) Species: 9606 (Homo sapiens) [Search protein sequence]
KIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNP
MDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLA
EVFEQEIDPVMQSL
3D structure
PDB5w0f GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9U7 A L1109 P1110 F1111 V1115 L1120 I1122 N1168 R1173 V1174 L27 P28 F29 V33 L38 I40 N86 R91 V92 MOAD: ic50=16nM
PDBbind-CN: -logKd/Ki=7.80,IC50=16nM
BindingDB: IC50=16nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5w0f, PDBe:5w0f, PDBj:5w0f
PDBsum5w0f
PubMed28892380
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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