Structure of PDB 5vzs Chain A

Receptor sequence
>5vzsA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5vzs GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of CBP/P300
ChainA
Resolution1.707 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9U4 A W81 F83 L92 L94 Y97 Y139 N140 W40 F42 L51 L53 Y56 Y98 N99 BindingDB: IC50=5100nM
External links
PDB RCSB:5vzs, PDBe:5vzs, PDBj:5vzs
PDBsum5vzs
PubMed
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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