Structure of PDB 5vxc Chain A

Receptor sequence
>5vxcA (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
HKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKNEARLR
IVKTLEDIDLGPTEKCVRVNSVSSGLAEEDLETLLQSRVLPSSLMLPKVE
SPEEIQWFADKFSFHLKGRKLEQPMNLIPFVETAMGLLNFKAVCEETLKV
GPQVGLFLDAVVFGGEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQ
AIDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQFSPSPE
KIKWAEELIAAFKEHQQLGKGAFTFQGSMIDMPLLKQAQNTVTLATSIKE
K
3D structure
PDB5vxc The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12.
ChainA
Resolution1.872 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.-
2.3.3.9: malate synthase.
3.1.2.30: (3S)-malyl-CoA thioesterase.
4.1.3.25: (S)-citramalyl-CoA lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A Y50 K57 K58 K61 R107 I272 H273 P274 Y11 K18 K19 K22 R68 I233 H234 P235
BS02 MG A E171 D206 E132 D167
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004474 malate synthase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0047777 (S)-citramalyl-CoA lyase activity
Biological Process
GO:0070207 protein homotrimerization
GO:0106064 regulation of cobalamin metabolic process
GO:0106121 positive regulation of cobalamin metabolic process
Cellular Component
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5vxc, PDBe:5vxc, PDBj:5vxc
PDBsum5vxc
PubMed29056341
UniProtQ8N0X4|CLYBL_HUMAN Citramalyl-CoA lyase, mitochondrial (Gene Name=CLYBL)

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