Structure of PDB 5vxa Chain A

Receptor sequence
>5vxaA (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
GSEAAQLLEAADFAARKHRQQRRKDPEGTPYINHPIGVARILTHEAGITD
IVVLQAALLHDTVEKTDTTLDEVELHFGAQVRRLVEEVTDDKTLPKLERK
RLQVEQAPHSSPGAKLVKLADKLYNLRDLNRCTPEGWSEHRVQEYFEWAA
QVVKGLQGTNRQLEEALKHLFKQRGLTI
3D structure
PDB5vxa MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.7.2: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H35 H61 D62 D122 H34 H60 D61 D121
BS02 NDP A R24 K25 Y32 H35 K66 K97 L98 K101 N126 D129 L130 W138 H141 R142 E145 Y146 R23 K24 Y31 H34 K65 K96 L97 K100 N125 D128 L129 W137 H140 R141 E144 Y145
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5vxa, PDBe:5vxa, PDBj:5vxa
PDBsum5vxa
PubMed32462112
UniProtQ8N4P3|MESH1_HUMAN Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (Gene Name=HDDC3)

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