Structure of PDB 5vx2 Chain A

Receptor sequence
>5vx2A (length=151) Species: 9606,10090 [Search protein sequence]
DDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
E
3D structure
PDB5vx2 Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
ChainA
Resolution1.851 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V216 H224 A227 M231 L235 R248 V249 H252 V253 D256 N260 G262 R263 V265 F318 F319 V45 H53 A56 M60 L64 R77 V78 H81 V82 D85 N89 G91 R92 V94 F147 F148
BS02 peptide A R222 N223 H224 E225 T226 A227 R51 N52 H53 E54 T55 A56
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5vx2, PDBe:5vx2, PDBj:5vx2
PDBsum5vx2
PubMed29149594
UniProtP97287|MCL1_MOUSE Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Gene Name=Mcl1);
Q07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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