Structure of PDB 5vwu Chain A

Receptor sequence

>5vwuA (length=494) Species: 746128 (Aspergillus fumigatus)

HPDISVDVLVIGAGPTGLGAAKRLNQIDGPSWMIVDSNETPGGLASTDVT
PEGFLYDVGGHVIFSHYKYFDDCLDEALPKEDDWYTHQRISYVRCQGQWV
PYPFQNNISMLPKEEQVKCIDGMIDAALEARVANTKPKTFDEWIVRMMGT
GIADLFMRPYNFKVWAVPTTKMQCAWLGERVAAPNLKAVTTNVILGKATF
RFPARGGTGGIWIAVANTLPKEKTRFGEKGKVTKVNANNKTVTLQDGTTI
GYKKLVSTMAVDFLAEAMNDQELVGLTKQLFYSSTHVIGVGVRGSRPEGD
KCWLYFPEDNCPFYRATIFSNYSPYNQPEASAALPTMQLADGSRPQSTEA
KEGPYWSIMLEVSESSMKPVNQETILADCIQGLVNTEMLKPTDEIVSTYH
RRFDHGYPTPTLEREGTLTQILPKLQDKDIWSRGRFGSWRYEVGNQDHSF
MLGVEAVDNIVNGAVELTLNYPDFVNGRQNTERRLVDGAQVFAK

3D structure

• PDB: 5vwu Identification of the NAD(P)H binding site of eukaryotic UDP-galactopyranose mutase.
• Chain: A
• Resolution: 2.75 Å

Enzymatic activity

• Enzyme Commision number: 5.4.99.9: UDP-galactopyranose mutase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G14 G16 P17 T18 D38 S39 G45 L46 G61 V242 M269 T295 R327 E373 R447 G456 N457 Q458 S461	G12 G14 P15 T16 D36 S37 G43 L44 G59 V232 M259 T285 R315 E361 R435 G444 N445 Q446 S449
BS02	NAI	A	I65 H68 R91 S93 Y104 Y419 R447 Y453 N457	I63 H66 R89 S91 Y102 Y407 R435 Y441 N445

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0008767 UDP-galactopyranose mutase activity
• GO:0016853 isomerase activity

Biological Process

• GO:0071555 cell wall organization

External links

• PDB: RCSB:5vwu, PDBe:5vwu, PDBj:5vwu
• PDBsum: 5vwu
• PubMed: 23036087
• UniProt: Q4W1X2|GLFA_ASPFM UDP-galactopyranose mutase (Gene Name=glfA)