Structure of PDB 5vsv Chain A

Receptor sequence

>5vsvA (length=343) Species: 1502 (Clostridium perfringens)

ARILKTAYTFDDVLLVPNKSEVLPNEVSLKTQLTKKIQLNIPLMSASMDT
VTESKMAIAMAREGGIGIIHKNMTIEDQAREVDRVKRSGGLLCGASIGVT
NDMMERVDAVVKAKVDVIVLDTAHGHSKGVIEGVKRIKAKYPELQVIAGN
IATPEAVRDLAEAGADCVKVGIGPGSICTTRIVAGVGVPQLTAVMDCAEE
GKKLGIPVIADGGLKYSGDIVKALAAGACAAMMGSIFAGCEEAPGAIEIY
QGRSYKVYRGMGSLGAMAKFVPEGVEGRIAYKGHLADTIYQLIGGIKSGM
GYLGAPTLENLYENANFVVQTSAGFRESHPHDINITKEAPNYS

3D structure

• PDB: 5vsv Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P225
• Chain: A
• Resolution: 2.205 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	IMP	A	M49 G300 S301 I302 C303 D336 G337 G338 M358 G359 S360 G385 M386 G387 E411	M48 G175 S176 I177 C178 D211 G212 G213 M233 G234 S235 G260 M261 G262 E273
BS02	8KY	A	T247 A248 H249 M386 G387 M392 E411	T122 A123 H124 M261 G262 M267 E273
BS03	8KY	A	P25 S436 G439 Y440	P24 S298 G301 Y302

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0003938 IMP dehydrogenase activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0006164 purine nucleotide biosynthetic process

External links

• PDB: RCSB:5vsv, PDBe:5vsv, PDBj:5vsv
• PDBsum: 5vsv
• UniProt: A0A127ELD1