Structure of PDB 5vsm Chain A

Receptor sequence
>5vsmA (length=258) Species: 10090 (Mus musculus) [Search protein sequence]
VSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKQAGLEKINF
SGGEPFLQDRGEYLGKLVRFCKEELALPSVSIVSNGSLIRERWFKDYGEY
LDILAISCDSFDEQVNALIGRGQGKKNHVENLQKLRRWCRDYKVAFKINS
VINRFNVDEDMNEHIKALSPVRWKVFQCLLIEGENSGEDALREAERFLIS
NEEFETFLERHKEVSCLVPESNQKMKDSYLILDEYMRFLNCTDPSKSILD
VGVEEAIK
3D structure
PDB5vsm Structural studies of viperin, an antiviral radical SAM enzyme.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) C84 C88 C91
Catalytic site (residue number reindexed from 1) C11 C15 C18
Enzyme Commision number 4.2.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 A C84 Y86 C88 C91 G126 N158 R194 C11 Y13 C15 C18 G53 N85 R121
BS02 MET A S124 G125 G126 V156 S157 S180 S51 G52 G53 V83 S84 S107
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0051607 defense response to virus
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid droplet

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5vsm, PDBe:5vsm, PDBj:5vsm
PDBsum5vsm
PubMed28607080
UniProtQ8CBB9|RSAD2_MOUSE S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (Gene Name=Rsad2)

[Back to BioLiP]