Structure of PDB 5vqn Chain A

Receptor sequence

>5vqnA (length=179) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1)))

GSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFM
YSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENR
FIDIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEE
SRARIKTRLFTIRQEMASRSLWDSFRQSE

3D structure

• PDB: 5vqn Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors.
• Chain: A
• Resolution: 2.002 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	A	H41 D108 D119 I120	H44 D92 D103 I104
BS02	MN	A	E80 D108	E64 D92
BS03	R07	A	A20 Y24 E26 K34 A37 I38 H41 L106 D108	A23 Y27 E29 K37 A40 I41 H44 L90 D92

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:5vqn, PDBe:5vqn, PDBj:5vqn
• PDBsum: 5vqn
• PubMed: 29691337
• UniProt: C3W5S0