Structure of PDB 5vq6 Chain A

Receptor sequence
>5vq6A (length=155) Species: 9606 (Homo sapiens) [Search protein sequence]
HMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDSYRKQVVIDGETCLLD
ILDTADQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVL
VGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREI
RKHKE
3D structure
PDB5vq6 Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.
ChainA
Resolution1.99 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSP A G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 A146 K147 G14 V15 G16 K17 S18 A19 F29 D31 N103 K104 D106 L107 S132 A133 K134
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5vq6, PDBe:5vq6, PDBj:5vq6
PDBsum5vq6
PubMed29199977
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

[Back to BioLiP]