Structure of PDB 5vpt Chain A

Receptor sequence
>5vptA (length=179) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1))) [Search protein sequence]
GSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFM
YSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENR
FIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEE
SRARIKTRLFTIRQEMASRSLWDSFRQSE
3D structure
PDB5vpt Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H41 D108 E119 I120 H44 D92 E103 I104
BS02 MN A E80 D108 E64 D92
BS03 R07 A Y24 A37 I38 H41 D108 E119 K134 Y27 A40 I41 H44 D92 E103 K118 MOAD: Kd=9.5nM
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5vpt, PDBe:5vpt, PDBj:5vpt
PDBsum5vpt
PubMed29691337
UniProtC3W5S0

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