Structure of PDB 5vo6 Chain A

Receptor sequence
>5vo6A (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
TIFEERHLKYISQLGGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDF
QREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHR
ARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADF
GLAKLLPLDKDYYVVPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYC
DKSCSPSAEFLRMMGVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCW
APSPQDRPSFSALGPQLDMLW
3D structure
PDB5vo6 Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors.
ChainA
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D949 A951 R953 N954 D967
Catalytic site (residue number reindexed from 1) D131 A133 R135 N136 D149
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9J4 A V836 A853 M902 E903 Y904 L905 G908 L956 V18 A35 M84 E85 Y86 L87 G90 L138 PDBbind-CN: -logKd/Ki=9.05,IC50=0.9nM
BindingDB: IC50=0.900000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5vo6, PDBe:5vo6, PDBj:5vo6
PDBsum5vo6
PubMed28539220
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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