Structure of PDB 5vn4 Chain A

Receptor sequence
>5vn4A (length=237) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]
HHMSLVEVLPNYFTLSKDSPLRKKFEKVYKWYSPAFSPHDVPRFAEVGNI
TENPEVMRGIRDFFVDRYKNLQQPITHILGFDSRGFLLGPMIAVELNVPF
VLIRKANKIAGVIIKSEPYTKEYAAESEECMTVRFGSFDKNSRVVLIDDV
IATGGTMLAGVQLVDACGATLVEVAGILGLTFLKGTQPAHTFAGGRYSNV
PFVTLVDETVLSDENCGDPLHHKGSRIISCAEAKKLI
3D structure
PDB5vn4 Crystal structure of adenine phosphoribosyl transferase from Trypanosoma brucei in complex with AMP, pyrophosphate, and ribose-5-phosphate
ChainA
Resolution1.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R82 E120
Catalytic site (residue number reindexed from 1) R84 E122
Enzyme Commision number 2.4.2.7: adenine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADE A F42 A43 R82 E120 Y121 V148 F44 A45 R84 E122 Y123 V150
BS02 HSX A R82 K119 E120 Y121 D146 D147 V148 A150 T151 G152 T154 R84 K121 E122 Y123 D148 D149 V150 A152 T153 G154 T156
Gene Ontology
Molecular Function
GO:0003999 adenine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
Cellular Component
GO:0005737 cytoplasm
GO:0020015 glycosome
GO:0031981 nuclear lumen
GO:0097014 ciliary plasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:5vn4, PDBe:5vn4, PDBj:5vn4
PDBsum5vn4
PubMed
UniProtQ57V32

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