Structure of PDB 5vmv Chain A

Receptor sequence

>5vmvA (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]

DDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYPCRYCEKV
FPLAEYRTKHEIHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSGD
SKLYRLHPCRSLQIRQ

3D structure

PDB

5vmv CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso.

Chain

Resolution

2.313 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R501 Y503 V504 C505 S508 R511 E535 Q563 R595	R21 Y23 V24 C25 S28 R31 E55 Q83 R115	PDBbind-CN: Kd=0.43nM
BS02	dna	A	R511 Y522 A534 E535 T538 R549 Y550 Y562 S578 G579 Y584 R595	R31 Y42 A54 E55 T58 R69 Y70 Y82 S98 G99 Y104 R115	PDBbind-CN: Kd=0.43nM
BS03	ZN	A	C496 C499 H512 H516	C16 C19 H32 H36
BS04	ZN	A	C524 C527 H540 H544	C44 C47 H60 H64
BS05	ZN	A	C552 C555 H568 H573	C72 C75 H88 H93

External links

PDB	RCSB:5vmv, PDBe:5vmv, PDBj:5vmv
PDBsum	5vmv
PubMed	29546986
UniProt	Q86T24\|KAISO_HUMAN Transcriptional regulator Kaiso (Gene Name=ZBTB33)