Structure of PDB 5vml Chain A

Receptor sequence
>5vmlA (length=245) Species: 320372 (Burkholderia pseudomallei 1710b) [Search protein sequence]
SQRIAYVTGGMGGIGTSICQRLHKDGFRVVAGCGPNSPRRVKWLEDQKAL
GFDFYASEGNVGDWDSTKQAFDKVKAEVGEIDVLVNNAGITRDVVFRKMT
REDWQAVIDTNLTSLFNVTKQVIDGMVERGWGRIINISSVNGQKGQFGQT
NYSTAKAGIHGFTMSLAQEVATKGVTVNTVSPGYIGTDMVKAIRPDVLEK
IVATIPVRRLGSPDEIGSIVAWLASEESGFSTGADFSLNGGLHMG
3D structure
PDB5vml Crystal Structure of Acetoacetyl-CoA Reductase from Burkholderia Pseudomallei 1710b with bound NADP
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G16 N114 S142 Y155 K159
Catalytic site (residue number reindexed from 1) G13 N111 S139 Y152 K156
Enzyme Commision number 1.1.1.36: acetoacetyl-CoA reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G12 G15 G16 I17 C36 G37 R42 G62 N63 V64 N90 G92 I93 S142 Y155 K159 P185 G186 I188 G9 G12 G13 I14 C33 G34 R39 G59 N60 V61 N87 G89 I90 S139 Y152 K156 P182 G183 I185
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0018454 acetoacetyl-CoA reductase activity
Biological Process
GO:0042619 poly-hydroxybutyrate biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:5vml, PDBe:5vml, PDBj:5vml
PDBsum5vml
PubMed
UniProtQ3JRS9

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