Structure of PDB 5vlc Chain A

Receptor sequence

>5vlcA (length=431) Species: 3880 (Medicago truncatula)

PIKTYHLSNLTQTELLSLKSRPRISVFDIVNPIVDDVHAHGDAAVKQYTS
KFDKVDLENIVELVSDLPDPVLDPAIKEAFDVAYSNIYAFHAAQKSPEKS
VENMKGVQCKRVARSINSVGLYVPGGTAVLPSTALMLAVPAQIAGCKTIV
LANPPTRDGTTCKEVLYCAKKAGVTHLLKAGGAQAISAMAWGTETCPKVE
KIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVIADKHAIPSHVAA
DLLSQAEHGPDSQVVLVIAGDGVDQNAIQEEVSKQCQSLPRGEFAAKALS
HSFIVHARDMLEAITFSNMYAPEHLIINVKDAEKWESFIENAGSVFLGSW
TPESVGDYASGTNHVLPTYGYARMYSGVSLDSFLKYITVQSLTEEGLRKL
GPYVETMAEVEGLEAHKRAVTLRLQDIEARQ

3D structure

• PDB: 5vlc Structures of Medicago truncatula L-Histidinol Dehydrogenase Show Rearrangements Required for NAD(+) Binding and the Cofactor Positioned to Accept a Hydride.
• Chain: A
• Resolution: 1.97 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Q299 H302 E367 H368 D401 H460
• Catalytic site (residue number reindexed from 1): Q255 H258 E323 H324 D357 H416
• Enzyme Commision number: 1.1.1.23: histidinol dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HSO	A	H302 E367 H368 D401 Y402 H408	H258 E323 H324 D357 Y358 H364
BS02	ZN	A	Q299 H302 D401	Q255 H258 D357
BS03	HSO	A	E455 H460	E411 H416

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004399 histidinol dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• GO:0046872 metal ion binding
• GO:0051287 NAD binding

Biological Process

• GO:0000105 L-histidine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0009507 chloroplast

External links

• PDB: RCSB:5vlc, PDBe:5vlc, PDBj:5vlc
• PDBsum: 5vlc
• PubMed: 28874718
• UniProt: G7IKX3