Structure of PDB 5vkm Chain A

Receptor sequence
>5vkmA (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
KWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKATSKFD
GTRLYESTKDGPSEQKRVQFLGDKNKNCTLSIHPVHLADSGQLGLRMESK
TEKWMERIHLAVSERPFPPHIQLPPEIQESQEVTLTCLLAFSCYGYPIQL
QWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDA
DGKFLSADTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEY
TTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVF
LQVQYA
3D structure
PDB5vkm Molecular basis of human CD22 function and therapeutic targeting.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL A Y64 F71 Y42 F49 PDBbind-CN: -logKd/Ki=3.55,Kd=281uM
BS02 SIA A R120 E126 W128 M129 R96 E102 W104 M105 PDBbind-CN: -logKd/Ki=3.55,Kd=281uM
External links
PDB RCSB:5vkm, PDBe:5vkm, PDBj:5vkm
PDBsum5vkm
PubMed28970495
UniProtP20273|CD22_HUMAN B-cell receptor CD22 (Gene Name=CD22)

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