Structure of PDB 5vkc Chain A

Receptor sequence
>5vkcA (length=144) Species: 9606 (Homo sapiens) [Search protein sequence]
MDLYRQSLEIISRYLREQATGAKSGATSRKALETLRRVGDGVQRNHETAF
QGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHL
KTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVE
3D structure
PDB5vkc Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
ChainA
Resolution2.31 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9EA A V220 H224 A227 F228 M231 M250 V253 G262 R263 T266 L267 F270 V42 H46 A49 F50 M53 M72 V75 G84 R85 T88 L89 F92 PDBbind-CN: -logKd/Ki=8.74,Ki=1.8nM
BindingDB: Ki=98nM
BS02 ZN A H252 D256 H74 D78
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5vkc, PDBe:5vkc, PDBj:5vkc
PDBsum5vkc
PubMed25679114
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

[Back to BioLiP]