Structure of PDB 5vk4 Chain A

Receptor sequence
>5vk4A (length=324) Species: 485 (Neisseria gonorrhoeae) [Search protein sequence]
DAGDQLVEKIKPFAKRTMRPEVLGALVEIGKKYQNPVLVSGTDGVGTKLK
LAFDWDKHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVPRATDV
IKGIAQGCEESGCALIGGETAEMPGMYPVGEYDLAGFAVGVVEKENVITG
LSVGAGDMVLGLASNGAHSNGYSLIRKIIERDNPDLDAEFDNGKTLREAV
IAPTRLYVKPILAALEKFTIKGMAHITGGGITENVPRVLPKNTVAQIDAE
SWELPKLFQWLQKAGNVETQEMYRTFNCGIGMVVIVAAEDADAVRSFLSG
QGETVYRLGCIRERQGNEHQTQVA
3D structure
PDB5vk4 Crystal structure of a phosphoribosylformylglycinamidine cyclo-ligase from Neisseria gonorrhoeae bound to AMPPNP and magnesium
ChainA
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.3.1: phosphoribosylformylglycinamidine cyclo-ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A V21 D105 G137 G138 E139 T140 V7 D85 G117 G118 E119 T120
BS02 MG A D63 D92 D43 D72
BS03 ANP A D63 D92 T247 R257 D43 D72 T227 R237
Gene Ontology
Molecular Function
GO:0004637 phosphoribosylamine-glycine ligase activity
GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0046084 adenine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:5vk4, PDBe:5vk4, PDBj:5vk4
PDBsum5vk4
PubMed
UniProtQ5F973|PUR5_NEIG1 Phosphoribosylformylglycinamidine cyclo-ligase (Gene Name=purM)

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