Structure of PDB 5vjw Chain A

Receptor sequence
>5vjwA (length=298) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
KPRTVICVGDIHGYISKLNNLWLNLQSAIDPSDFSSALVIFLGDYCDRGP
ETRKVIDFLISLPEKHPDQTHVFLAGNHDFAFSGFLGLLPRPSDGSDLKD
TWKEYSKSEETEGWYTGEGFEDMHLQGRRWAGKIKAAYKGSIYDAGSTFE
SYGVPHGSSDLMKAVPESHKKFLTNMVWVHEEDDVCIETEEGLKHCKLIA
VHAGLEKGNNVEEQLKLLRAKDTSISKIQHLSGRKNVWDIPQELDDKHTV
VVSGHHGKLHIDGMRLIIDEGGGFPDKPVAAIVLPSKKIIRDTDNLSS
3D structure
PDB5vjw Structural basis for the preference of the Arabidopsis thalianaphosphatase RLPH2 for tyrosine-phosphorylated substrates.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D47 N80 H213 H266 D44 N77 H202 H255
BS02 ZN A D13 H15 D47 D10 H12 D44
BS03 WO4 A H15 D47 R51 N80 H81 R245 H266 H12 D44 R48 N77 H78 R234 H255
BS04 WO4 A R132 K238 R129 K227
Gene Ontology
Molecular Function
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035970 peptidyl-threonine dephosphorylation
GO:0070262 peptidyl-serine dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:5vjw, PDBe:5vjw, PDBj:5vjw
PDBsum5vjw
PubMed29615518
UniProtQ9SR62|RLPH2_ARATH Tyrosine-protein phosphatase RLPH2 (Gene Name=RLPH2)

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