Structure of PDB 5vja Chain A

Receptor sequence
>5vjaA (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
SMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRRGVSREEI
EREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESL
TEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLID
FGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILL
SGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPK
RRMTIAQSLEHSWIKA
3D structure
PDB5vja Targeting Pim Kinases and DAPK3 to Control Hypertension.
ChainA
Resolution2.46 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D139 K141 E143 N144 D161 T180
Catalytic site (residue number reindexed from 1) D128 K130 E132 N133 D150 T169
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DUK A L19 G20 V27 K42 V96 M146 I160 D161 L13 G14 V21 K36 V85 M135 I149 D150 PDBbind-CN: -logKd/Ki=6.59,Ki=0.260uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5vja, PDBe:5vja, PDBj:5vja
PDBsum5vja
PubMed30033129
UniProtO43293|DAPK3_HUMAN Death-associated protein kinase 3 (Gene Name=DAPK3)

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