Structure of PDB 5vie Chain A

Receptor sequence
>5vieA (length=666) Species: 9606 (Homo sapiens) [Search protein sequence]
RLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADA
YSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPE
AIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQL
EKNLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKD
LKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDG
TNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARN
ELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAY
MPHTFFIGDHANMFPHLKKKAVIDFIYDNRIVLNGIDLKAFLDSLPDVKI
VNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGE
EVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNS
VLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVC
LDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAK
NRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYL
QMWEHYAAGNKPDHMI
3D structure
PDB5vie Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.255: protein O-GlcNAc transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H496 H498 N557 P559 T633 K634 V895 H158 H160 N219 P221 T295 K296 V534
BS02 UDP A K842 F868 V895 A896 K898 H901 H920 T921 T922 D925 K481 F507 V534 A535 K537 H540 H559 T560 T561 D564 BindingDB: IC50=1800nM
BS03 9C1 A H498 T560 L563 L653 P656 F694 Y841 C917 H920 H160 T222 L225 L315 P318 F356 Y480 C556 H559
External links
PDB RCSB:5vie, PDBe:5vie, PDBj:5vie
PDBsum5vie
PubMed29058723
UniProtO15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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