Structure of PDB 5vdk Chain A

Receptor sequence
>5vdkA (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
MASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNE
NSALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISE
NTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKVMY
KIGDLGHATSINKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAV
AAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPS
AAALARNTVL
3D structure
PDB5vdk Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D339 K341
Catalytic site (residue number reindexed from 1) D136 K138
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8X7 A V220 G221 E222 V226 A239 N289 E290 Y291 C292 G295 F346 V17 G18 E19 V23 A36 N86 E87 Y88 C89 G92 F143 PDBbind-CN: -logKd/Ki=7.57,Kd=27.0nM
BindingDB: Kd=3.9nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5vdk, PDBe:5vdk, PDBj:5vdk
PDBsum5vdk
PubMed28792760
UniProtP0C1S8|WEE2_HUMAN Wee1-like protein kinase 2 (Gene Name=WEE2)

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