Structure of PDB 5vd1 Chain A

Receptor sequence
>5vd1A (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
LGTENLYFQSLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRL
GHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQ
HPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRD
TLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEV
QEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLR
QGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ
3D structure
PDB5vd1 Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D233 K235 N238 D251 D270
Catalytic site (residue number reindexed from 1) D167 K169 N172 D185 D204
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P48 A L116 Y121 V124 A137 K139 C190 G191 P192 Q196 F240 D251 L50 Y55 V58 A71 K73 C124 G125 P126 Q130 F174 D185 MOAD: Kd=990nM
PDBbind-CN: -logKd/Ki=6.00,Kd=990nM
BindingDB: Kd=990nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5vd1, PDBe:5vd1, PDBj:5vd1
PDBsum5vd1
PubMed28792760
UniProtQ99640|PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Gene Name=PKMYT1)

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