Structure of PDB 5vcw Chain A

Receptor sequence
>5vcwA (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
LQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFK
VRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQA
WEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHS
QGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAP
ELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTA
GLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ
3D structure
PDB5vcw Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D233 K235 N238 D251 D270
Catalytic site (residue number reindexed from 1) D157 K159 N162 D175 D194
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 93J A L116 K139 V171 T187 C190 G191 P192 Q196 F240 L40 K63 V95 T111 C114 G115 P116 Q120 F164 MOAD: Kd=1105nM
PDBbind-CN: -logKd/Ki=5.96,Kd=1105nM
BindingDB: Kd=2900nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5vcw, PDBe:5vcw, PDBj:5vcw
PDBsum5vcw
PubMed28792760
UniProtQ99640|PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Gene Name=PKMYT1)

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