Structure of PDB 5vb6 Chain A

Receptor sequence
>5vb6A (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMW
EMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVR
MCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSE
DEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA
KLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSGGGEKHK
ILHRLLQDS
3D structure
PDB5vb6 Structural studies unravel the active conformation of apo ROR gamma t nuclear receptor and a common inverse agonism of two diverse classes of ROR gamma t inhibitors.
ChainA
Resolution2.041 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 927 A L287 W317 C320 H323 L324 M365 R367 F388 H479 Y502 L23 W53 C56 H59 L60 M101 R103 F124 H215 Y238 MOAD: Kd=0.43uM
PDBbind-CN: -logKd/Ki=6.37,Kd=0.43uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5vb6, PDBe:5vb6, PDBj:5vb6
PDBsum5vb6
PubMed28546429
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC);
Q15596

[Back to BioLiP]