Structure of PDB 5var Chain A

Receptor sequence
>5varA (length=108) Species: 9606 (Homo sapiens) [Search protein sequence]
QSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDI
VSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQL
VVKRDDVY
3D structure
PDB5var Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach.
ChainA
Resolution1.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.66: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69: [histone H3]-trimethyl-L-lysine(36) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 92Y A F932 D934 S936 W967 Y973 F36 D38 S40 W71 Y77 MOAD: Kd=81.7uM
PDBbind-CN: -logKd/Ki=4.09,Kd=81.7uM
BindingDB: Kd=80000nM
External links
PDB RCSB:5var, PDBe:5var, PDBj:5var
PDBsum5var
PubMed29691138
UniProtO75164|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)

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