Structure of PDB 5vaq Chain A

Receptor sequence

>5vaqA (length=861) Species: 9606 (Homo sapiens)

FSGDGRAIWSLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFI
HTHLKGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAK
GLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFND
YATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVG
HNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPQRSENTMDIFKCQ
QSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFF
AFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWF
TDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQD
AYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQGQ
FPCDFSWGVTESVLKPECTDFVNIKKQLEMLARMKVTHYRFALDWASVLP
TGQLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHA
DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDT
YGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHW
RAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTE
AERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSS
PTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLG
KYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFY
NKVISSRGFPF

3D structure

• PDB: 5vaq Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
• Chain: A
• Resolution: 2.606 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	F379 K380 V392 W419 F420 D422 Y434 M435 S532 Y643 P644 H646 N692 E693 R696 L697 H743 F826 R829 R845 Q848 F849 L850 I853 F931 F942	F309 K310 V322 W349 F350 D352 Y364 M365 S462 Y535 P536 H538 N584 E585 R588 L589 H635 F718 R721 R737 Q740 F741 L742 I745 F823 F834

Gene Ontology

Molecular Function

• GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
• GO:0005104 fibroblast growth factor receptor binding
• GO:0005515 protein binding
• GO:0017134 fibroblast growth factor binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0008284 positive regulation of cell population proliferation
• GO:0008543 fibroblast growth factor receptor signaling pathway
• GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:5vaq, PDBe:5vaq, PDBj:5vaq
• PDBsum: 5vaq
• PubMed: 29342135
• UniProt: Q86Z14|KLOTB_HUMAN Beta-klotho (Gene Name=KLB)