Structure of PDB 5van Chain A

Receptor sequence
>5vanA (length=861) Species: 9606 (Homo sapiens) [Search protein sequence]
FSGDGRAIWSQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHF
IHTHLGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAK
GLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFND
YATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVG
HNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPQRSENTMDIFKCQ
QSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFF
AFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWF
TDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQD
AYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQGQ
FPCDFSWGVTESVLKPEQCTDFVNIKKQLEMLARMKVTHYRFALDWASVL
PTGQLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLH
ADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGND
TYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSH
WRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLT
EAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLS
SPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYL
GKYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQF
YNKVISSRGFP
3D structure
PDB5van Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
ChainA
Resolution2.202 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGC A L612 R617 Q679 L505 R510 Q572
BS02 BGC A S733 Q734 S626 Q627
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0017134 fibroblast growth factor binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:5van, PDBe:5van, PDBj:5van
PDBsum5van
PubMed29342135
UniProtQ86Z14|KLOTB_HUMAN Beta-klotho (Gene Name=KLB)

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