Structure of PDB 5vaj Chain A

Receptor sequence
>5vajA (length=135) Species: 272558 (Halalkalibacterium halodurans C-125) [Search protein sequence]
EIIWESLSVDVGSQGNPGIVEYKGVDTKTGEVLFEREPIPIGTNNMGEFL
AIVHGLRYLKERNSRKPIYSNSQTAIKWVKDKKAKSTLVRNEETALIWKL
VDEAEEWLNTHTYETPILKWQTDKWGEIKADYGRK
3D structure
PDB5vaj Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A D71 S74 Q75 G76 N105 E109 N132 Q134 K180 T183 D10 S13 Q14 G15 N44 E48 N71 Q73 K119 T122
BS02 dna A N77 P78 T104 N105 N106 K138 W139 S147 T148 N16 P17 T43 N44 N45 K77 W78 S86 T87
BS03 MG A D71 E109 N132 D10 E48 N71
BS04 MG A D71 D192 D10 D131
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:5vaj, PDBe:5vaj, PDBj:5vaj
PDBsum5vaj
PubMed28854734
UniProtQ9KEI9|RNH1_HALH5 Ribonuclease H (Gene Name=rnhA)

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