Structure of PDB 5v9u Chain A

Receptor sequence
>5v9uA (length=169) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
SLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKHKEK
3D structure
PDB5v9u Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
ChainA
Resolution1.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 91S A C12 K16 P34 A59 G60 E62 R68 M72 H95 Y96 Q99 V103 C12 K16 P34 A59 G60 E62 R68 M72 H95 Y96 Q99 V103
BS02 GDP A G13 V14 G15 K16 S17 A18 F28 V29 D30 N116 K117 D119 S145 A146 G13 V14 G15 K16 S17 A18 F28 V29 D30 N116 K117 D119 S145 A146
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5v9u, PDBe:5v9u, PDBj:5v9u
PDBsum5v9u
PubMed29373830
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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