Structure of PDB 5v5z Chain A

Receptor sequence

>5v5zA (length=488) Species: 237561 (Candida albicans SC5314) [Search protein sequence]

ILLGVPFVYNLVWQYLYSLRKDRAPLVFYWIPWFGSAASYGQQPYEFFES
CRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTP
VFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDE
SFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDL
DKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNR
DLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLG
EKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHM
PLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDP
TRWDTSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTT
FVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEKRE

3D structure

PDB

5v5z Crystal Structures of Full-Length Lanosterol 14 alpha-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.14.154: sterol 14alpha-demethylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEM	A	Y118 Y132 K143 I304 G308 T311 P375 I379 R381 P462 F463 H468 C470	Y94 Y108 K119 I280 G284 T287 P351 I355 R357 P426 F427 H432 C434
BS02	1YN	A	A61 Y118 I131 Y132 P230 G303 G307 T311 L376 H377 F380 Y505 S506 M508	A37 Y94 I107 Y108 P206 G279 G283 T287 L352 H353 F356 Y469 S470 M472

Gene Ontology

	Molecular Function
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008398	sterol 14-demethylase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0001766	membrane raft polarization
GO:0006696	ergosterol biosynthetic process
GO:0007032	endosome organization
GO:0016126	sterol biosynthetic process
GO:0036187	cell growth mode switching, budding to filamentous

	Cellular Component
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032541	cortical endoplasmic reticulum
GO:0097038	perinuclear endoplasmic reticulum

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5v5z, PDBe:5v5z, PDBj:5v5z
PDBsum	5v5z
PubMed	30126961
UniProt	P10613\|CP51_CANAL Lanosterol 14-alpha demethylase (Gene Name=ERG11)

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