Structure of PDB 5v57 Chain A

Receptor sequence

>5v57A (length=645) Species: 882,9606

PPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLV
LWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIV
ERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWY
EDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWR
NSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPT
SNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKT
SYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAP
IGLVLIVGGYFLIRGVMTLFSIKSNHAKALIVYGSTTGNTEYTAETIARE
LADAGYEVDSRDAASVEAGGLFEGFDLVLLGCSTWGDDSIELQDDFIPLF
DSLEETGAQGRKVACFGCGDSSWEYFCGAVDAIEEKLKNLGAEIVQDGLR
IDGDPRAARDDIVGWAHDVRGAIKINETMLRLGIFGFLAFGFVLITFSCH
FYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKI
NLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDHHHHHHH

3D structure

• PDB: 5v57 Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.
• Chain: A
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	836	A	N219 M230 W281 D384 S387 F391 Y394 R400 Q477 W480 E481 P513 E518 N521	N162 M173 W224 D327 S330 F334 Y337 R343 Q557 W560 E561 P593 E598 N601
BS02	FMN	A	S1010 T1011 T1012 G1013 N1014 T1015 S1058 T1059 W1060 G1061 C1093 G1094 D1095 W1098 Y1100 F1101	S385 T386 T387 G388 N389 T390 S433 T434 W435 G436 C468 G469 D470 W473 Y475 F476

Gene Ontology

Molecular Function

• GO:0004888 transmembrane signaling receptor activity
• GO:0009055 electron transfer activity
• GO:0010181 FMN binding

Biological Process

• GO:0007166 cell surface receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5v57, PDBe:5v57, PDBj:5v57
• PDBsum: 5v57
• PubMed: 28513578
• UniProt: P00323|FLAV_NITV2 Flavodoxin (Gene Name=DVU_2680);
  Q99835|SMO_HUMAN Protein smoothened (Gene Name=SMO)