Structure of PDB 5v42 Chain A

Receptor sequence
>5v42A (length=268) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
GFVRTLRARPEAGGKVPVFVFHPAGGSTVVYEPLLGRLPADTPMYGFERV
EGSIEERAQQYVPKLIEMQGDGPYVLVGWSLGGVLAYACAIGLRRLGKDV
RFVGLIDAVRAGEEIPQTKEEIRKRWDRYAAFAEKTFNVPAIPYEQLEEL
DDEGQVRFVLDAVSQIPAGIIEHQRTSYLDNRAIDTAQIQPYDGHVTLYM
ADRYHDDAIMFEPRYAVRQPDGGWGEYVSDLEVVPIGGEHIQAIDEPIIA
KVGEHMSRALGQIEADRT
3D structure
PDB5v42 Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
ChainA
Resolution1.987 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I66 A S1636 Y1637 N1640 D1644 F1670 Y1674 S177 Y178 N181 D185 F211 Y215 MOAD: ic50=0.24uM
PDBbind-CN: -logKd/Ki=6.62,IC50=0.24uM
Gene Ontology
Biological Process
GO:0009058 biosynthetic process

View graph for
Biological Process
External links
PDB RCSB:5v42, PDBe:5v42, PDBj:5v42
PDBsum5v42
PubMed28669536
UniProtI6X8D2|PKS13_MYCTU Polyketide synthase Pks13 (Gene Name=pks13)

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