Structure of PDB 5v41 Chain A

Receptor sequence
>5v41A (length=272) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
DGFVRTLRARPEAGGKVPVFVFHPAGGSTVVYEPLLGRLPADTPMYGFER
VEGSIEERAQQYVPKLIEMQGDGPYVLVGWSLGGVLAYACAIGLRRLGKD
VRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAAFAEKTFNVPAIPYEQLEE
LDDEGQVRFVLDAVSQSVQIPAGIIEHQRTSYLDNRAIDTAQIQPYDGHV
TLYMADRYHDDAIMFEPRYAVRQPDGGWGEYVSDLEVVPIGGEHIQAIDE
PIIAKVGEHMSRALGQIEADRT
3D structure
PDB5v41 Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
ChainA
Resolution2.051 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J24 A Y1582 S1636 Y1637 N1640 I1643 D1644 A1667 F1670 Y1674 Y130 S181 Y182 N185 I188 D189 A212 F215 Y219 MOAD: ic50=0.71uM
PDBbind-CN: -logKd/Ki=6.15,IC50=0.71uM
Gene Ontology
Biological Process
GO:0009058 biosynthetic process

View graph for
Biological Process
External links
PDB RCSB:5v41, PDBe:5v41, PDBj:5v41
PDBsum5v41
PubMed28669536
UniProtI6X8D2|PKS13_MYCTU Polyketide synthase Pks13 (Gene Name=pks13)

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