Structure of PDB 5v36 Chain A

Receptor sequence
>5v36A (length=451) Species: 210007 (Streptococcus mutans UA159) [Search protein sequence]
AMTKQYDYIVIGGGSGGIASANRAAMHGAKVILFEGKQVGGTCVNVGCVP
KKVMWYGAQVAETINNYAADYGFDVTTQAFHFDVLKQNRQAYIDRIHDSY
ERGFDSNGVERVYGYATFVDAHTVEVAGEHYTAPHILIATGGHALLPDIP
GSEYGITSDGFFELDAIPKRTAVVGAGYIAVEISGILHALGSETHLFVRR
DRPLRKFDKEIVGTLVDEMKKDGPHLHTFSVPKEVIKNTDNSLTLILENG
EEYTVDTLIWAIGRAANTKGFNLEVTGVTLDSRGFIATDAFENTNVEGLY
ALGDVNGKLELTPVAVKAGRQLSERLFNHKPQAKMDYKDVATVIFSHPVI
GSIGLSEEAALDQYGEENVTVYRSTFTSMYTAVTSHRQACKMKLVTVGED
EKIVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTM
R
3D structure
PDB5v36 1.88 Angstrom Resolution Crystal Structure of Glutathione Reductase from Streptococcus mutans UA159 in Complex with FAD.
ChainA
Resolution1.88 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V38 C42 C47 K50 Y177 E181 A437 H439 E444
Catalytic site (residue number reindexed from 1) V39 C43 C48 K51 Y178 E182 A438 H440 E445
Enzyme Commision number 1.8.1.7: glutathione-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A I10 G13 S14 G15 E34 G35 G40 T41 C42 G46 C47 K50 Y114 A115 T139 G140 Y177 I178 R263 F270 G302 D303 L310 T311 I11 G14 S15 G16 E35 G36 G41 T42 C43 G47 C48 K51 Y115 A116 T140 G141 Y178 I179 R264 F271 G303 D304 L311 T312
BS02 BDF A Y410 G411 D413 Y411 G412 D414
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004362 glutathione-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0034599 cellular response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:5v36, PDBe:5v36, PDBj:5v36
PDBsum5v36
PubMed
UniProtQ8DUR5

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