Structure of PDB 5v2l Chain A

Receptor sequence
>5v2lA (length=321) Species: 226185 (Enterococcus faecalis V583) [Search protein sequence]
AMLSGKARAHTNIALIKYWGKANEEYILPMNSSLSLTLDAFYTETTVTFD
AHYSEDVFILNGILQNEKQTKKVKEFLNLVRQQADCTWFAKVESQNFVPT
AAGLASSASGLAALAGACNVALGLNLSAKDLSRLARRGSGSACRSIFGGF
AQWNKGHSDETSFAENIPANNWENELAMLFILINSSRDGMKRTVETSSFY
QGWLDNVEKDLSQVHEAIKTKDFPRLGEIIEANGLRMHGTTLGAVPPFTY
WSPGSLQAMALVRQARAKGIPCYFTMDAGPNVKVLVEKKNLEALKTFLSE
HFSKEQLVPAFAGPGIELFET
3D structure
PDB5v2l Mevalonate 5-diphosphate mediates ATP binding to the mevalonate diphosphate decarboxylase from the bacterial pathogen Enterococcus faecalis.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.33: diphosphomevalonate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A F57 V72 S93 N95 A104 G109 F58 V73 S94 N96 A105 G110 PDBbind-CN: -logKd/Ki=3.54,Kd=288uM
BS02 PO4 A Y17 K20 G139 R192 Y18 K21 G140 R187
Gene Ontology
Molecular Function
GO:0004163 diphosphomevalonate decarboxylase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016829 lyase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5v2l, PDBe:5v2l, PDBj:5v2l
PDBsum5v2l
PubMed29025876
UniProtQ837E0

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