Structure of PDB 5v1b Chain A

Receptor sequence
>5v1bA (length=226) Species: 9606 (Homo sapiens) [Search protein sequence]
PSAPERLALDYIVPCMRYYGICVVDSFLGAALGGRVLAEVEALKRGGRLR
QLVSPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYKIN
GRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLL
QIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDA
DERARAKDKYQLASGQKGVQVPVSQP
3D structure
PDB5v1b 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction.
ChainA
Resolution2.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.-
1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H297 D299 H358 H120 D122 H181
BS02 8UY A Y287 Y294 H297 I311 Y313 H358 V360 R367 A369 Y110 Y117 H120 I134 Y136 H181 V183 R190 A192 MOAD: ic50=0.034uM
PDBbind-CN: -logKd/Ki=7.47,IC50=0.034uM
BindingDB: IC50=34.0nM
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:5v1b, PDBe:5v1b, PDBj:5v1b
PDBsum5v1b
PubMed28594552
UniProtQ96KS0|EGLN2_HUMAN Prolyl hydroxylase EGLN2 (Gene Name=EGLN2)

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