Structure of PDB 5v18 Chain A

Receptor sequence
>5v18A (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
QTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTG
KFTDGQLVSQKDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKI
NGRTKAMVACYPGNGTYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGIL
RIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDA
DERARAGEKGVRVEL
3D structure
PDB5v18 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8UY A Y303 Y310 H313 Y329 H374 V376 R383 A385 Y111 Y117 H120 Y136 H181 V183 R190 A192
BS02 FE2 A H313 D315 H374 H120 D122 H181
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:5v18, PDBe:5v18, PDBj:5v18
PDBsum5v18
PubMed28594552
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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