Structure of PDB 5uzp Chain A

Receptor sequence
>5uzpA (length=436) Species: 9606 (Homo sapiens) [Search protein sequence]
ASSTNLKDILADLIPKEQARIKTFRQQHGKTVVGQITVDMMYGGMRGMKG
LVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLFWLLVTGH
IPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNS
ESNFARAYAQGISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGI
GAIDSNLDWSHNFTNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHL
VGSALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEK
LRDYIWNTLNSGRVVPGYGHGVLRKTDPRYTCQREFALKHLPNDPMFKLV
AQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVS
RALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDS
3D structure
PDB5uzp Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase.
ChainA
Resolution2.29 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S271 H301 H347 R356 D402
Catalytic site (residue number reindexed from 1) S244 H274 H320 R329 D375
Enzyme Commision number 2.3.3.1: citrate (Si)-synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OAA A N269 H301 R356 R428 N242 H274 R329 R401
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004108 citrate (Si)-synthase activity
GO:0016740 transferase activity
GO:0036440 citrate synthase activity
GO:0042802 identical protein binding
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0006101 citrate metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uzp, PDBe:5uzp, PDBj:5uzp
PDBsum5uzp
PubMed31141475
UniProtO75390|CISY_HUMAN Citrate synthase, mitochondrial (Gene Name=CS)

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