Structure of PDB 5uyz Chain A

Receptor sequence
>5uyzA (length=493) Species: 9606 (Homo sapiens) [Search protein sequence]
LEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM
MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHP
IRIADGYEQAARVAIERLDKISDSVLVDIKDTEPLIQTAKSCHRQMAEIA
VNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQM
PKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMI
QQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGG
RIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCAVTIFIRGGNKM
IIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTL
EQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDC
LHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKP
3D structure
PDB5uyz Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy.
ChainA
Resolution3.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D73 T106 T107 D404
Catalytic site (residue number reindexed from 1) D43 T76 T77 D361
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A L52 G53 G105 T106 T107 G422 L494 V506 E508 L22 G23 G75 T76 T77 G379 L451 V463 E465
Gene Ontology
Molecular Function
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0031681 G-protein beta-subunit binding
GO:0044183 protein folding chaperone
GO:0048027 mRNA 5'-UTR binding
GO:0048487 beta-tubulin binding
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0009615 response to virus
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0050821 protein stabilization
GO:0051086 chaperone mediated protein folding independent of cofactor
GO:0061077 chaperone-mediated protein folding
GO:1904871 positive regulation of protein localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0044297 cell body
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uyz, PDBe:5uyz, PDBj:5uyz
PDBsum5uyz
PubMed28623285
UniProtP48643|TCPE_HUMAN T-complex protein 1 subunit epsilon (Gene Name=CCT5)

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