Structure of PDB 5uxn Chain A

Receptor sequence
>5uxnA (length=445) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
SWSPESWRAKPIQQQPEYPDAAHLARVEQTLAGYPPLVFAGEARELRRQF
AEVTAGRAFLLQGGDCAESFAEFSAAKIRDTFKVLLQMAVVMTFAAGCPV
VKVGRMAGQFAKPRSSGDETQNGVTLPAYRGDIVNGIGFDEKSRVPDPER
LLQAYHQSTASLNLLRAFAQGGFADLHQVHRWNLDFIANSALAERYQQLA
DRIDETLAFMRACGLDSAPQLRETSFFTAHEALLLNYEEALTRRDSLTGE
WYDCSAHMLWIGDRTRQIDGAHVEMLRGVGNPIGVKVGPSMDSEELIRLI
DILNPDNDPGRLNLIVRMGADKVGDHLPRLIQAIQREGRQVLWSSDPMHG
NTIKASSGYKTRDFARVLAEVRQFFEVHQAEGSYAGGIHIEMTGQNVTEC
IGGSRPITEDGLSDRYHTHCDPRLNADQSLELAFLIAETLKQVRR
3D structure
PDB5uxn A Pseudoisostructural Type II DAH7PS Enzyme from Pseudomonas aeruginosa: Alternative Evolutionary Strategies to Control Shikimate Pathway Flux.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A D23 H26 D20 H23
BS02 PO4 A R117 S118 K363 R114 S115 K360
BS03 CO A C69 H352 E394 D424 C66 H349 E391 D421
BS04 PEP A R108 G265 K289 R320 H352 R105 G262 K286 R317 H349
BS05 TYR A A177 L179 Q223 E226 T227 A174 L176 Q220 E223 T224 MOAD: Kd=23uM
PDBbind-CN: -logKd/Ki=4.64,Kd=23uM
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740 transferase activity
Biological Process
GO:0009073 aromatic amino acid family biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5uxn, PDBe:5uxn, PDBj:5uxn
PDBsum5uxn
PubMed29608284
UniProtQ9I000

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