Structure of PDB 5uxm Chain A

Receptor sequence
>5uxmA (length=445) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
SWSPESWRAKPIQQQPEYPDAAHLARVEQTLAGYPPLVFAGEARELRRQF
AEVTAGRAFLLQGGDCAESFAEFSAAKIRDTFKVLLQMAVVMTFAAGCPV
VKVGRMAGQFAKPRSSGDETQNGVTLPAYRGDIVNGIGFDEKSRVPDPER
LLQAYHQSTASLNLLRAFAQGGFADLHQVHRWNLDFIANSALAERYQQLA
DRIDETLAFMRACGLDSAPQLRETSFFTAHEALLLNYEEALTRRDSLTGE
WYDCSAHMLWIGDRTRQIDGAHVEMLRGVGNPIGVKVGPSMDSEELIRLI
DILNPDNDPGRLNLIVRMGADKVGDHLPRLIQAIQREGRQVLWSSDPMHG
NTIKASSGYKTRDFARVLAEVRQFFEVHQAEGSYAGGIHIEMTGQNVTEC
IGGSRPITEDGLSDRYHTHCDPRLNADQSLELAFLIAETLKQVRR
3D structure
PDB5uxm A Pseudoisostructural Type II DAH7PS Enzyme from Pseudomonas aeruginosa: Alternative Evolutionary Strategies to Control Shikimate Pathway Flux.
ChainA
Resolution1.54 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PEP A R108 G265 R267 K289 R320 H352 R105 G262 R264 K286 R317 H349
BS02 TRP A V93 K105 A177 L179 Q223 E226 V90 K102 A174 L176 Q220 E223 MOAD: Kd=3.6uM
PDBbind-CN: -logKd/Ki=5.44,Kd=3.6uM
BS03 PO4 A R117 S118 K357 K363 R114 S115 K354 K360
BS04 PO4 A D23 H26 D20 H23
BS05 CO A C69 H352 E394 D424 C66 H349 E391 D421
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740 transferase activity
Biological Process
GO:0009073 aromatic amino acid family biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5uxm, PDBe:5uxm, PDBj:5uxm
PDBsum5uxm
PubMed29608284
UniProtQ9I000

[Back to BioLiP]