Structure of PDB 5uw5 Chain A

Receptor sequence
>5uw5A (length=696) Species: 39387 (Gypsophila vaccaria) [Search protein sequence]
PLHYPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQEKLANS
VLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQNVFQM
QDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSGLTEWVTI
KILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPNQEARYHFLGT
DQSEDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDANKVYCLDLT
KLPNGLESFAPFMKLIDSFDASYTAIANDGSVFTFQTNKDAPRKKLVRVD
LNNPSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHVLEIRDLESG
ALQHRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQCDLKNDPTQL
KIFRESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGISLDGSHPCE
MHGYGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEYGEEWHKAGF
RDKKQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLVAACINQRPD
LFGCAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKWLIKYSPIHN
VRRPWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATMQHVLCTSLE
DSPQKNPIIARIQRKAAAYGRATMTQIAEVADRYGFMAKALEAPWI
3D structure
PDB5uw5 Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.
ChainA
Resolution2.94 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y481 S562 D653 A695
Catalytic site (residue number reindexed from 1) Y454 S535 D626 A668
Enzyme Commision number 3.4.21.-
3.4.21.26: prolyl oligopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R81 F95 N104 L132 F492 S493 A494 S495 T700 V707 R73 F87 N96 L124 F465 S466 A467 S468 T673 V680
BS02 CA A E61 E64 E53 E56
BS03 CA A A717 E719 A690 E692
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
GO:0070012 oligopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uw5, PDBe:5uw5, PDBj:5uw5
PDBsum5uw5
PubMed28584123
UniProtR4P353

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