Structure of PDB 5uuv Chain A

Receptor sequence
>5uuvA (length=346) Species: 1392 (Bacillus anthracis) [Search protein sequence]
NAMWESKFVKEGLTFDDVLLVPAKSDVLPREVSVKTVLSESLQLNIPLIS
AGMDTVTEADMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSGGLLVGA
AVGVTADAMTRIDALVKASVDAIVLDTAHGHSQGVIDKVKEVRAKYPSLN
IIAGNVATAEATKALIEAGANVVKVGIGPGSICTTRVVAGVGVPQLTAVY
DCATEARKHGIPVIADGGIKYSGDMVKALAAGAHVVMLGSMFAGVAESPG
ETEIYQGRQFKVYRGMGSVGAMEVPEGIEGRVPYKGPLADTVHQLVGGLR
AGMGYCGAQDLEFLRENAQFIRMSGAGLLESHPHHVQITKEAPNYS
3D structure
PDB5uuv Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Bacillus anthracis in the complex with a product IMP and the inhibitor P182
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP A M51 G305 S306 I307 C308 D341 G342 G343 G364 S365 Y388 G390 M391 G392 E416 M53 G180 S181 I182 C183 D216 G217 G218 G239 S240 Y263 G265 M266 G267 E276
BS02 8L1 A T252 A253 H254 M391 G392 E416 T127 A128 H129 M266 G267 E276
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5uuv, PDBe:5uuv, PDBj:5uuv
PDBsum5uuv
PubMed
UniProtA0A6L8P2U9

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