Structure of PDB 5uum Chain A

Receptor sequence
>5uumA (length=156) Species: 9606 (Homo sapiens) [Search protein sequence]
GSDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDG
VQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLIS
FGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFF
HVEDLE
3D structure
PDB5uum Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
ChainA
Resolution2.346 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H224 M231 K234 K238 N239 R248 V249 H252 V253 D256 N260 G262 R263 T266 F318 F319 H55 M62 K65 K69 N70 R79 V80 H83 V84 D87 N91 G93 R94 T97 F149 F150
BS02 ZN A E317 H320 E322 E148 H151 E153
BS03 ZN A D236 D242 H277 D67 D73 H108
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5uum, PDBe:5uum, PDBj:5uum
PDBsum5uum
PubMed28594323
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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