Structure of PDB 5uuk Chain A

Receptor sequence
>5uukA (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVE
KNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGIL
IKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFE
PK
3D structure
PDB5uuk Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
ChainA
Resolution1.199 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N51 C55 N58 V59 Q73 V74 K77 E78 N85 G87 R88 T91 K147 F148 N52 C56 N59 V60 Q74 V75 K78 E79 N86 G88 R89 T92 K148 F149
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5uuk, PDBe:5uuk, PDBj:5uuk
PDBsum5uuk
PubMed28594323
UniProtQ16548|B2LA1_HUMAN Bcl-2-related protein A1 (Gene Name=BCL2A1)

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